Assay Detail
Binding
CHEMBL4477359
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NF-kappaB (unknown origin) expressed in mouse RAW264.7 cells pretreated for 1 hr followed by stimulation with LPS measured after 6 hrs by luciferase reporter gene assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | RAW264.7 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Eremophilane-Type Sesquiterpenoids from an Acremonium sp. Fungus Isolated from Deep-Sea Sediments.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.23 | 4.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL399491 | PYRROLIDINE DITHIOCARBAMATE | — | 1 | 4.43 |
| CHEMBL4558418 | — | — | 1 | 4.14 |
| CHEMBL4529119 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL399491 | PYRROLIDINE DITHIOCARBAMATE | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL4558418 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL4529119 | — | IC50 | = | 78000.0 | nM | 4.11 |