Assay Detail
Binding
CHEMBL4477397
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse microsomal 11beta-HSD1 overexpressed in HEK293 cells using [3H]-cortisone as substrate assessed as formation of [3H]-cortisol using [3H]cortisone by scintillation proximity assay in presence of NADPH
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL3910) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Limonoids and Triterpenoids as 11β-HSD1 Inhibitors from Walsura robusta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.32 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230006 | ENOXOLONE | 2.0 | 1 | 8.03 |
| CHEMBL4532570 | — | — | 1 | 6.16 |
| CHEMBL1508930 | — | — | 1 | 6.06 |
| CHEMBL4551399 | — | — | 1 | 5.92 |
| CHEMBL4529492 | — | — | 1 | 5.42 |
| CHEMBL4575439 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230006 | ENOXOLONE | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL4532570 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1508930 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL4551399 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4529492 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4575439 | — | IC50 | - | — | - |