Assay Detail
Functional
CHEMBL4477866
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human VCaP cells after 96 hrs by propidium iodide staining based fluorescence 2D monolayer assay
117
Total Activities
111
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | VCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 111 | 4.55 | 5.56 |
| IC70 | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4572299 | — | — | 2 | 5.56 |
| CHEMBL4574367 | — | — | 1 | 5.53 |
| CHEMBL4527234 | — | — | 1 | 5.37 |
| CHEMBL4581453 | — | — | 1 | 5.35 |
| CHEMBL4555717 | — | — | 2 | 5.28 |
| CHEMBL4552599 | — | — | 1 | 5.23 |
| CHEMBL4483683 | — | — | 1 | 5.12 |
| CHEMBL4523011 | — | — | 1 | 5.08 |
| CHEMBL4572778 | — | — | 1 | 5.06 |
| CHEMBL4517405 | — | — | 1 | 5.05 |
| CHEMBL4534919 | — | — | 1 | 5.04 |
| CHEMBL4525680 | — | — | 1 | 5.04 |
| CHEMBL4556247 | — | — | 1 | 5.03 |
| CHEMBL4589154 | — | — | 1 | 5.02 |
| CHEMBL4529026 | — | — | 1 | 5.02 |
| CHEMBL4514116 | — | — | 1 | 5.01 |
| CHEMBL4561198 | — | — | 1 | 5.00 |
| CHEMBL4544466 | — | — | 1 | 4.99 |
| CHEMBL4524380 | — | — | 1 | 4.96 |
| CHEMBL4483784 | — | — | 1 | 4.94 |
| CHEMBL4575144 | — | — | 1 | 4.91 |
| CHEMBL4580745 | — | — | 1 | 4.89 |
| CHEMBL4547536 | — | — | 1 | 4.88 |
| CHEMBL4520750 | — | — | 1 | 4.80 |
| CHEMBL4578289 | — | — | 1 | 4.78 |
| CHEMBL4538279 | — | — | 1 | 4.78 |
| CHEMBL4554887 | — | — | 1 | 4.78 |
| CHEMBL4516007 | — | — | 1 | 4.77 |
| CHEMBL4587958 | — | — | 1 | 4.76 |
| CHEMBL4580562 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4572299 | — | IC50 | = | 2778.0 | nM | 5.56 |
| CHEMBL4574367 | — | IC50 | = | 2950.0 | nM | 5.53 |
| CHEMBL4527234 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL4581453 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL4555717 | — | IC50 | = | 5267.0 | nM | 5.28 |
| CHEMBL4552599 | — | IC50 | = | 5860.0 | nM | 5.23 |
| CHEMBL4483683 | — | IC50 | = | 7510.0 | nM | 5.12 |
| CHEMBL4523011 | — | IC50 | = | 8380.0 | nM | 5.08 |
| CHEMBL4572778 | — | IC50 | = | 8640.0 | nM | 5.06 |
| CHEMBL4517405 | — | IC50 | = | 8910.0 | nM | 5.05 |
| CHEMBL4525680 | — | IC50 | = | 9040.0 | nM | 5.04 |
| CHEMBL4534919 | — | IC50 | = | 9230.0 | nM | 5.04 |
| CHEMBL4556247 | — | IC50 | = | 9280.0 | nM | 5.03 |
| CHEMBL4589154 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL4529026 | — | IC50 | = | 9610.0 | nM | 5.02 |
| CHEMBL4514116 | — | IC50 | = | 9650.0 | nM | 5.01 |
| CHEMBL4561198 | — | IC50 | = | 9910.0 | nM | 5.00 |
| CHEMBL4544466 | — | IC50 | = | 10280.0 | nM | 4.99 |
| CHEMBL4524380 | — | IC50 | = | 10910.0 | nM | 4.96 |
| CHEMBL4483784 | — | IC50 | = | 11490.0 | nM | 4.94 |
| CHEMBL4575144 | — | IC50 | = | 12390.0 | nM | 4.91 |
| CHEMBL4580745 | — | IC50 | = | 12790.0 | nM | 4.89 |
| CHEMBL4547536 | — | IC50 | = | 13260.0 | nM | 4.88 |
| CHEMBL4520750 | — | IC50 | = | 15880.0 | nM | 4.80 |
| CHEMBL4554887 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL4538279 | — | IC50 | = | 16640.0 | nM | 4.78 |
| CHEMBL4578289 | — | IC50 | = | 16510.0 | nM | 4.78 |
| CHEMBL4516007 | — | IC50 | = | 17070.0 | nM | 4.77 |
| CHEMBL4587958 | — | IC50 | = | 17180.0 | nM | 4.76 |
| CHEMBL4580562 | — | IC50 | = | 17360.0 | nM | 4.76 |
| CHEMBL4526555 | — | IC50 | = | 17390.0 | nM | 4.76 |
| CHEMBL4516292 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL4545964 | — | IC50 | = | 17590.0 | nM | 4.75 |
| CHEMBL4587634 | — | IC50 | = | 18270.0 | nM | 4.74 |
| CHEMBL4559439 | — | IC50 | = | 18290.0 | nM | 4.74 |
| CHEMBL4483369 | — | IC50 | = | 18560.0 | nM | 4.73 |
| CHEMBL4576882 | — | IC50 | = | 18640.0 | nM | 4.73 |
| CHEMBL4578972 | — | IC50 | = | 18820.0 | nM | 4.72 |
| CHEMBL4557177 | — | IC50 | = | 18920.0 | nM | 4.72 |
| CHEMBL4591244 | — | IC50 | = | 19340.0 | nM | 4.71 |
| CHEMBL4519421 | — | IC50 | = | 19550.0 | nM | 4.71 |
| CHEMBL4544680 | — | IC50 | = | 19500.0 | nM | 4.71 |
| CHEMBL4574456 | — | IC50 | = | 20270.0 | nM | 4.69 |
| CHEMBL4579280 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL4533200 | — | IC50 | = | 20920.0 | nM | 4.68 |
| CHEMBL4527657 | — | IC50 | = | 21590.0 | nM | 4.67 |
| CHEMBL4587862 | — | IC50 | = | 21170.0 | nM | 4.67 |
| CHEMBL4514435 | — | IC50 | = | 21930.0 | nM | 4.66 |
| CHEMBL4560812 | — | IC50 | = | 22370.0 | nM | 4.65 |
| CHEMBL4582085 | — | IC50 | = | 23020.0 | nM | 4.64 |