Assay Detail
Functional
CHEMBL4478033
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Cytotoxicity against mouse L1210 cells assessed as cell growth inhibition
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L1210 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.90 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308086 | DUOCARMYCIN | — | 1 | 11.00 |
| CHEMBL4583938 | — | — | 1 | 10.40 |
| CHEMBL4578928 | — | — | 1 | 10.30 |
| CHEMBL146774 | — | — | 1 | 10.00 |
| CHEMBL4520221 | — | — | 1 | 9.82 |
| CHEMBL4546940 | — | — | 1 | 9.15 |
| CHEMBL4544619 | — | — | 1 | 8.66 |
| CHEMBL293412 | — | — | 1 | 8.22 |
| CHEMBL1081390 | — | — | 1 | 7.22 |
| CHEMBL4520945 | — | — | 1 | 7.16 |
| CHEMBL4524401 | — | — | 1 | 5.96 |
| CHEMBL4589036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308086 | DUOCARMYCIN | IC50 | = | 0.01 | nM | 11.00 |
| CHEMBL4583938 | — | IC50 | = | 0.04 | nM | 10.40 |
| CHEMBL4578928 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL146774 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL4520221 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL4546940 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4544619 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL293412 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1081390 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4520945 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4524401 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4589036 | — | IC50 | = | 0.004 | nM | - |