Assay Detail
Binding
CHEMBL4478199
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Inhibition of GSK3beta (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.26 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4593348 | — | — | 1 | 6.26 |
| CHEMBL4560522 | — | — | 1 | - |
| CHEMBL4218734 | — | — | 1 | - |
| CHEMBL4166405 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4593348 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4560522 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4218734 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4166405 | — | IC50 | > | 100000.0 | nM | - |