Assay Detail

CHEMBL4478510

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Functional

Cytotoxicity against human KMS-12-BM cells assessed as reduction in cell viability after 72 hrs by CellTiter-Glo luminescent assay

ChEMBL ↗

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Target

KMS-12-BM (CHEMBL4296455) ↗

Open DB target context

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KMS-12-BM (CHEMBL4296455) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target KMS-12-BM

CHEMBL4296455

Anchored from Assay target.

Protein identity KMS-12-BM

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	KMS-12-BM
Confidence	1 — Organism
Curated By	Autocuration

Target

KMS-12-BM (CHEMBL4296455) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Discovery and Optimization of Quinazolinone-pyrrolopyrrolones as Potent and Orally Bioavailable Pan-Pim Kinase Inhibitors.

Pettus LH, Andrews KL, Booker SK, Chen J, Cee VJ, Chavez F, Chen Y, Eastwood H, Guerrero N, Herberich B, Hickman D, Lanman BA, Laszlo J, Lee MR, Lipford JR, Mattson B, Mohr C, Nguyen Y, Norman MH, Powers D, Reed AB, Rex K, Sastri C, Tamayo N, Wang P, Winston JT, Wu B, Wu T, Wurz RP, Xu Y, Zhou Y, Tasker AS, Wang HL.
J Med Chem (2016) 59 : 6407 -6430
PubMed 27285051 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.58	6.58

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL3979678	—	—	1	6.58

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL3979678	—	IC50	=	260.0	nM	6.58