Assay Detail
Functional
CHEMBL4479170
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Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of viral DNA in cell supernatant incubated for 3 days in presence of 10% FBS followed by compound treatment in absence of 10% FBS for 3 days by qRT-PCR method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepatitis B virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Reduction Sensitive Lipid Conjugates of Tenofovir: Synthesis, Stability, and Antiviral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 5.99 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4574633 | — | — | 1 | 7.70 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | 4.0 | 1 | 6.47 |
| CHEMBL4591641 | — | — | 1 | 6.35 |
| CHEMBL4559882 | — | — | 1 | 6.30 |
| CHEMBL4522332 | — | — | 1 | 5.78 |
| CHEMBL4590974 | — | — | 1 | 4.94 |
| CHEMBL4557355 | — | — | 1 | 4.38 |
| CHEMBL4535399 | — | — | 1 | - |
| CHEMBL4536590 | — | — | 1 | - |
| CHEMBL4572472 | — | — | 1 | - |
| CHEMBL4583653 | — | — | 1 | - |
| CHEMBL4578738 | — | — | 1 | - |
| CHEMBL4529939 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4574633 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4591641 | — | EC50 | = | 444.0 | nM | 6.35 |
| CHEMBL4559882 | — | EC50 | = | 505.0 | nM | 6.30 |
| CHEMBL4522332 | — | EC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4590974 | — | EC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4557355 | — | EC50 | = | 41900.0 | nM | 4.38 |
| CHEMBL4535399 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4536590 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4572472 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4583653 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4578738 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4529939 | — | EC50 | > | 25000.0 | nM | - |