Assay Detail
Binding
CHEMBL4479285
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE preincubated for 6 mins followed by addition of acetylthiocholine iodide by Ellman's method
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of novel 1,2,3-triazole-based acetylcholinesterase inhibitors with neuroprotective activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 4.57 | 5.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 5.45 |
| CHEMBL4581664 | — | — | 1 | 5.14 |
| CHEMBL4525497 | — | — | 1 | 4.98 |
| CHEMBL4551175 | — | — | 1 | 4.92 |
| CHEMBL4525580 | — | — | 1 | 4.81 |
| CHEMBL4561751 | — | — | 1 | 4.69 |
| CHEMBL4581887 | — | — | 1 | 4.69 |
| CHEMBL4578074 | — | — | 1 | 4.67 |
| CHEMBL4513605 | — | — | 1 | 4.61 |
| CHEMBL4513836 | — | — | 1 | 4.56 |
| CHEMBL4524162 | — | — | 1 | 4.55 |
| CHEMBL4536296 | — | — | 1 | 4.52 |
| CHEMBL4521556 | — | — | 1 | 4.52 |
| CHEMBL4522818 | — | — | 1 | 4.52 |
| CHEMBL4516485 | — | — | 1 | 4.52 |
| CHEMBL4576458 | — | — | 1 | 4.50 |
| CHEMBL4541730 | — | — | 1 | 4.50 |
| CHEMBL4531267 | — | — | 1 | 4.49 |
| CHEMBL4584351 | — | — | 1 | 4.47 |
| CHEMBL4530986 | — | — | 1 | 4.45 |
| CHEMBL4572737 | — | — | 1 | 4.42 |
| CHEMBL4539017 | — | — | 1 | 4.42 |
| CHEMBL4571408 | — | — | 1 | 4.41 |
| CHEMBL4545234 | — | — | 1 | 4.39 |
| CHEMBL4589486 | — | — | 1 | 4.35 |
| CHEMBL4534953 | — | — | 1 | 4.34 |
| CHEMBL4549496 | — | — | 1 | 4.34 |
| CHEMBL4515828 | — | — | 1 | 4.22 |
| CHEMBL4547644 | — | — | 1 | 4.19 |
| CHEMBL4540499 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | IC50 | = | 3560.0 | nM | 5.45 |
| CHEMBL4581664 | — | IC50 | = | 7230.0 | nM | 5.14 |
| CHEMBL4525497 | — | IC50 | = | 10430.0 | nM | 4.98 |
| CHEMBL4551175 | — | IC50 | = | 12150.0 | nM | 4.92 |
| CHEMBL4525580 | — | IC50 | = | 15430.0 | nM | 4.81 |
| CHEMBL4561751 | — | IC50 | = | 20450.0 | nM | 4.69 |
| CHEMBL4581887 | — | IC50 | = | 20470.0 | nM | 4.69 |
| CHEMBL4578074 | — | IC50 | = | 21220.0 | nM | 4.67 |
| CHEMBL4513605 | — | IC50 | = | 24430.0 | nM | 4.61 |
| CHEMBL4513836 | — | IC50 | = | 27350.0 | nM | 4.56 |
| CHEMBL4524162 | — | IC50 | = | 28430.0 | nM | 4.55 |
| CHEMBL4536296 | — | IC50 | = | 30120.0 | nM | 4.52 |
| CHEMBL4521556 | — | IC50 | = | 30170.0 | nM | 4.52 |
| CHEMBL4522818 | — | IC50 | = | 30330.0 | nM | 4.52 |
| CHEMBL4516485 | — | IC50 | = | 30120.0 | nM | 4.52 |
| CHEMBL4576458 | — | IC50 | = | 31430.0 | nM | 4.50 |
| CHEMBL4541730 | — | IC50 | = | 31330.0 | nM | 4.50 |
| CHEMBL4531267 | — | IC50 | = | 32610.0 | nM | 4.49 |
| CHEMBL4584351 | — | IC50 | = | 34150.0 | nM | 4.47 |
| CHEMBL4530986 | — | IC50 | = | 35220.0 | nM | 4.45 |
| CHEMBL4572737 | — | IC50 | = | 37560.0 | nM | 4.42 |
| CHEMBL4539017 | — | IC50 | = | 38370.0 | nM | 4.42 |
| CHEMBL4571408 | — | IC50 | = | 39340.0 | nM | 4.41 |
| CHEMBL4545234 | — | IC50 | = | 40780.0 | nM | 4.39 |
| CHEMBL4589486 | — | IC50 | = | 44730.0 | nM | 4.35 |
| CHEMBL4534953 | — | IC50 | = | 45230.0 | nM | 4.34 |
| CHEMBL4549496 | — | IC50 | = | 46150.0 | nM | 4.34 |
| CHEMBL4515828 | — | IC50 | = | 60120.0 | nM | 4.22 |
| CHEMBL4547644 | — | IC50 | = | 64170.0 | nM | 4.19 |
| CHEMBL4540499 | — | IC50 | > | 100000.0 | nM | - |