Assay Detail
Binding
CHEMBL4479308
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human P2X7 receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent Suppressive Effects of 1-Piperidinylimidazole Based Novel P2X7 Receptor Antagonists on Cancer Cell Migration and Invasion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.69 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1823817 | CE-224535 | 2.0 | 1 | 8.40 |
| CHEMBL3415305 | — | — | 1 | 8.00 |
| CHEMBL4535840 | — | — | 1 | 7.29 |
| CHEMBL255787 | — | — | 1 | 7.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1823817 | CE-224535 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3415305 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4535840 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL255787 | — | IC50 | = | 90.0 | nM | 7.05 |