Assay Detail
Binding
CHEMBL4479309
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Antagonist activity at human P2X7 receptor expressed in HEK293 cells assessed as inhibition of BzATP-induced EtBr uptake measured after 2 hrs by fluorescence analysis
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent Suppressive Effects of 1-Piperidinylimidazole Based Novel P2X7 Receptor Antagonists on Cancer Cell Migration and Invasion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 7.15 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4165149 | — | — | 1 | 9.96 |
| CHEMBL3415305 | — | — | 1 | 9.64 |
| CHEMBL4582650 | — | — | 1 | 9.31 |
| CHEMBL4584526 | — | — | 1 | 8.83 |
| CHEMBL4561852 | — | — | 1 | 8.81 |
| CHEMBL4594110 | — | — | 1 | 8.15 |
| CHEMBL4542014 | — | — | 1 | 7.89 |
| CHEMBL4526937 | — | — | 1 | 7.60 |
| CHEMBL4521847 | — | — | 1 | 7.60 |
| CHEMBL4534068 | — | — | 1 | 7.57 |
| CHEMBL4592534 | — | — | 1 | 7.51 |
| CHEMBL4531777 | — | — | 1 | 7.50 |
| CHEMBL3741159 | — | — | 1 | 7.40 |
| CHEMBL4529842 | — | — | 1 | 7.39 |
| CHEMBL4582804 | — | — | 1 | 7.36 |
| CHEMBL4559257 | — | — | 1 | 7.35 |
| CHEMBL4570660 | — | — | 1 | 7.35 |
| CHEMBL4586600 | — | — | 1 | 7.26 |
| CHEMBL4585050 | — | — | 1 | 7.21 |
| CHEMBL3415342 | — | — | 1 | 7.16 |
| CHEMBL4529050 | — | — | 1 | 7.14 |
| CHEMBL4513283 | — | — | 1 | 7.11 |
| CHEMBL4536033 | — | — | 1 | 7.06 |
| CHEMBL4573595 | — | — | 1 | 6.96 |
| CHEMBL4560935 | — | — | 1 | 6.95 |
| CHEMBL4590758 | — | — | 1 | 6.84 |
| CHEMBL4535840 | — | — | 1 | 6.83 |
| CHEMBL4527934 | — | — | 1 | 6.82 |
| CHEMBL4582217 | — | — | 1 | 6.81 |
| CHEMBL4551449 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4165149 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL3415305 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL4582650 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL4584526 | — | IC50 | = | 1.49 | nM | 8.83 |
| CHEMBL4561852 | — | IC50 | = | 1.53 | nM | 8.81 |
| CHEMBL4594110 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4542014 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4526937 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4521847 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4534068 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4592534 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL4531777 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3741159 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4529842 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4582804 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4559257 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4570660 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4586600 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4585050 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3415342 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL4529050 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4513283 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4536033 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL4573595 | — | IC50 | = | 109.0 | nM | 6.96 |
| CHEMBL4560935 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4590758 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL4535840 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL4527934 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL4582217 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL4551449 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL4575784 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL4549063 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL4571782 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL4542468 | — | IC50 | = | 238.0 | nM | 6.62 |
| CHEMBL4483719 | — | IC50 | = | 244.0 | nM | 6.61 |
| CHEMBL4548337 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL4519323 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL4580923 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL4531079 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL4551632 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4537806 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4537272 | — | IC50 | = | 565.0 | nM | 6.25 |
| CHEMBL4588622 | — | IC50 | = | 702.0 | nM | 6.15 |
| CHEMBL4575046 | — | IC50 | = | 896.0 | nM | 6.05 |
| CHEMBL4544899 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL4527182 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL4533569 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL4538742 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4547543 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4548453 | — | IC50 | > | 10000.0 | nM | - |