Assay Detail
Binding
CHEMBL4479319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human P2X4 receptor expressed in human 1321N1 cells assessed as inhibition of ATP-induced calcium influx preincubated for 30 mins prior to ATP-stimulation by calcium influx assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent Suppressive Effects of 1-Piperidinylimidazole Based Novel P2X7 Receptor Antagonists on Cancer Cell Migration and Invasion.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.46 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180179 | — | — | 1 | 6.46 |
| CHEMBL265502 | SURAMIN | 3.0 | 1 | - |
| CHEMBL4160315 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180179 | — | IC50 | = | 348.0 | nM | 6.46 |
| CHEMBL265502 | SURAMIN | IC50 | - | — | - | |
| CHEMBL4160315 | — | IC50 | - | — | - |