Assay Detail
Binding
CHEMBL4479336
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kdelta in human PBMC assessed as reduction in cytostim-induced IFNgamma production after 20 hrs by electrochemiluminescence assay
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.00 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4434674 | — | — | 1 | 8.40 |
| CHEMBL4593011 | — | — | 1 | 6.70 |
| CHEMBL4564931 | — | — | 1 | 6.70 |
| CHEMBL4561692 | — | — | 2 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4434674 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL4593011 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4564931 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL4561692 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL4561692 | — | IC50 | = | 250.0 | nM | 6.60 |