Assay Detail
Functional
CHEMBL4479405
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Antiproliferative activity against human CWR22Rv1 cells after 7 days by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CWR22R |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of Novel Steroidal Androgen Receptor Degrading Agents Inspired by Galeterone 3β-Imidazole Carbamate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.42 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4552506 | — | — | 1 | 6.30 |
| CHEMBL4581336 | — | — | 1 | 6.09 |
| CHEMBL4593419 | — | — | 1 | 5.92 |
| CHEMBL4591875 | — | — | 1 | 5.59 |
| CHEMBL4541575 | — | — | 1 | 5.49 |
| CHEMBL4521939 | — | — | 1 | 5.12 |
| CHEMBL4532487 | — | — | 1 | 5.12 |
| CHEMBL4528465 | — | — | 1 | 5.06 |
| CHEMBL2105738 | GALETERONE | 3.0 | 1 | 5.05 |
| CHEMBL4588643 | — | — | 1 | 5.00 |
| CHEMBL4539707 | — | — | 1 | 4.91 |
| CHEMBL254328 | ABIRATERONE | 3.0 | 1 | - |
| CHEMBL1082407 | ENZALUTAMIDE | 4.0 | 1 | - |
| CHEMBL4520316 | — | — | 1 | - |
| CHEMBL4564188 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4552506 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4581336 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4593419 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4591875 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL4541575 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL4521939 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4532487 | — | IC50 | = | 7520.0 | nM | 5.12 |
| CHEMBL4528465 | — | IC50 | = | 8740.0 | nM | 5.06 |
| CHEMBL2105738 | GALETERONE | IC50 | = | 8910.0 | nM | 5.05 |
| CHEMBL4588643 | — | IC50 | = | 9880.0 | nM | 5.00 |
| CHEMBL4539707 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL254328 | ABIRATERONE | IC50 | - | — | - | |
| CHEMBL1082407 | ENZALUTAMIDE | IC50 | - | — | - | |
| CHEMBL4520316 | — | IC50 | - | — | - | |
| CHEMBL4564188 | — | IC50 | - | — | - |