Assay Detail
Binding
CHEMBL4479416
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of catalytic activity of constitutive proteasome 20s subunit beta5 in human RPMI8226 cells incubated for 1 hr by BODIPY(TMR)-NC-005-VS probe based competitive activity based protein profiling assay
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.56 | 6.56 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4522536 | — | — | 1 | 6.56 |
| CHEMBL4581001 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4522536 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL4581001 | — | Inhibition | - | % | - |