Assay Detail
Binding
CHEMBL4479671
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Inhibition of recombinant human 6His-tagged SENP1 catalytic domain expressed in Escherichia coli preincubated for 15 mins followed by addition of SUMO1-AMC as substrate measured after 1 hr by fluorescence analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Vialinin A and thelephantin G, potent inhibitors of tumor necrosis factor-α production, inhibit sentrin/SUMO-specific protease 1 enzymatic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.44 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4587307 | — | — | 1 | 5.82 |
| CHEMBL2012938 | VIALININ A | — | 1 | 5.72 |
| CHEMBL2012939 | — | — | 1 | 5.42 |
| CHEMBL4593579 | — | — | 1 | 5.21 |
| CHEMBL2013072 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4587307 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL2012938 | VIALININ A | IC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL2012939 | — | IC50 | = | 3760.0 | nM | 5.42 |
| CHEMBL4593579 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL2013072 | — | IC50 | = | 9730.0 | nM | 5.01 |