Assay Detail
Binding
CHEMBL4479677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MARK4 in mouse cortical neurons assessed as inhibition of okadaic acid-induced tau phosphorylation at S262 residue preincubated for 15 mins followed okadaic acid challenge for 1.5 hrs by immunostaining method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
MAP/microtubule affinity-regulating kinase 4 (CHEMBL4523387) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.44 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4568087 | — | — | 1 | 8.70 |
| CHEMBL4569508 | — | — | 1 | 7.30 |
| CHEMBL4550702 | — | — | 1 | 7.22 |
| CHEMBL4552628 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4568087 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4569508 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4550702 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4552628 | — | IC50 | = | 280.0 | nM | 6.55 |