Assay Detail
Binding
CHEMBL4479704
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full-length recombinant human GST and His-tagged CDK5/P25 expressed in baculovirus expression system by Z'-LYTE assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.76 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4568087 | — | — | 1 | 8.36 |
| CHEMBL4569508 | — | — | 1 | 7.72 |
| CHEMBL4552628 | — | — | 1 | 7.21 |
| CHEMBL4550702 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4568087 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL4569508 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4552628 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4550702 | — | IC50 | < | 10.0 | nM | - |