Assay Detail
Binding
CHEMBL4479707
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full-length recombinant human His-tagged CHEK1 expressed in baculovirus expression system by Z'-LYTE assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase Chk1 (CHEMBL4630) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.33 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4568087 | — | — | 1 | 8.66 |
| CHEMBL4569508 | — | — | 1 | 7.24 |
| CHEMBL4550702 | — | — | 1 | 6.72 |
| CHEMBL4552628 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4568087 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL4569508 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4550702 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4552628 | — | IC50 | = | 200.0 | nM | 6.70 |