Assay Detail
Binding
CHEMBL4479716
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human His-tagged cytoplasmic EPHA3 expressed in baculovirus expression system by LanthaScreen assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.23 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4568087 | — | — | 1 | 7.66 |
| CHEMBL4550702 | — | — | 1 | 7.28 |
| CHEMBL4569508 | — | — | 1 | 6.75 |
| CHEMBL4552628 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4568087 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4550702 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4569508 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4552628 | — | IC50 | > | 100000.0 | nM | - |