Assay Detail
Binding
CHEMBL4479780
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full-length recombinant human His-tagged SRC expressed in baculovirus expression system by Adapta assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.11 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4568087 | — | — | 1 | 8.52 |
| CHEMBL4569508 | — | — | 1 | 7.43 |
| CHEMBL4550702 | — | — | 1 | 7.38 |
| CHEMBL4552628 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4568087 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4569508 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4550702 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4552628 | — | IC50 | = | 8100.0 | nM | 5.09 |