Assay Detail
Binding
CHEMBL4480332
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Inhibition of calpain (unknown origin) using calpain substrate preincubated for 20 mins followed by substrate addition by fluorescence plate reader analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.49 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4520267 | — | — | 1 | 7.02 |
| CHEMBL2402203 | — | — | 1 | 6.22 |
| CHEMBL4590201 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4520267 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL2402203 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4590201 | — | IC50 | = | 600.0 | nM | 6.22 |