Assay Detail
Binding
CHEMBL4480339
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human aromatase using 7-methoxy-trifluoromethylcoumarin as substrate incubated for 30 mins by fluorescence microplate reader analysis
28
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and aromatase inhibitory evaluation of 4-N-nitrophenyl substituted amino-4H-1,2,4-triazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.62 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1444 | LETROZOLE | 4.0 | 2 | 8.66 |
| CHEMBL4574913 | — | — | 2 | 8.04 |
| CHEMBL4575939 | — | — | 2 | 7.92 |
| CHEMBL4560281 | — | — | 2 | 7.84 |
| CHEMBL4556775 | — | — | 2 | 7.76 |
| CHEMBL4514474 | — | — | 2 | 7.76 |
| CHEMBL4563511 | — | — | 2 | 7.71 |
| CHEMBL4592407 | — | — | 2 | 7.52 |
| CHEMBL4536893 | — | — | 2 | 7.40 |
| CHEMBL4526798 | — | — | 2 | 7.36 |
| CHEMBL4568674 | — | — | 2 | 7.24 |
| CHEMBL4564168 | — | — | 2 | 7.23 |
| CHEMBL4546916 | — | — | 2 | 7.14 |
| CHEMBL4547558 | — | — | 2 | 7.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1444 | LETROZOLE | IC50 | = | 2.178 | nM | 8.66 |
| CHEMBL1444 | LETROZOLE | IC50 | = | 2.18 | nM | 8.66 |
| CHEMBL4574913 | — | IC50 | = | 9.02 | nM | 8.04 |
| CHEMBL4574913 | — | IC50 | = | 9.016 | nM | 8.04 |
| CHEMBL4575939 | — | IC50 | = | 12.12 | nM | 7.92 |
| CHEMBL4575939 | — | IC50 | = | 12.11 | nM | 7.92 |
| CHEMBL4560281 | — | IC50 | = | 14.53 | nM | 7.84 |
| CHEMBL4560281 | — | IC50 | = | 14.52 | nM | 7.84 |
| CHEMBL4556775 | — | IC50 | = | 17.42 | nM | 7.76 |
| CHEMBL4514474 | — | IC50 | = | 17.38 | nM | 7.76 |
| CHEMBL4556775 | — | IC50 | = | 17.42 | nM | 7.76 |
| CHEMBL4514474 | — | IC50 | = | 17.38 | nM | 7.76 |
| CHEMBL4563511 | — | IC50 | = | 19.66 | nM | 7.71 |
| CHEMBL4563511 | — | IC50 | = | 19.68 | nM | 7.71 |
| CHEMBL4592407 | — | IC50 | = | 30.2 | nM | 7.52 |
| CHEMBL4592407 | — | IC50 | = | 30.19 | nM | 7.52 |
| CHEMBL4536893 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL4536893 | — | IC50 | = | 39.77 | nM | 7.40 |
| CHEMBL4526798 | — | IC50 | = | 43.55 | nM | 7.36 |
| CHEMBL4526798 | — | IC50 | = | 43.57 | nM | 7.36 |
| CHEMBL4568674 | — | IC50 | = | 57.54 | nM | 7.24 |
| CHEMBL4568674 | — | IC50 | = | 57.58 | nM | 7.24 |
| CHEMBL4564168 | — | IC50 | = | 58.88 | nM | 7.23 |
| CHEMBL4564168 | — | IC50 | = | 58.85 | nM | 7.23 |
| CHEMBL4546916 | — | IC50 | = | 73.11 | nM | 7.14 |
| CHEMBL4546916 | — | IC50 | = | 73.17 | nM | 7.14 |
| CHEMBL4547558 | — | IC50 | = | 90.78 | nM | 7.04 |
| CHEMBL4547558 | — | IC50 | = | 90.73 | nM | 7.04 |