Assay Detail

CHEMBL4480495

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Functional

Trypanocidal activity against Trypanosoma brucei gambiense

ChEMBL ↗

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Target

Trypanosoma brucei gambiense (CHEMBL613768) ↗

Open DB target context

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Trypanosoma brucei gambiense (CHEMBL613768) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Trypanosoma brucei gambiense

CHEMBL613768

Anchored from Assay target.

Protein identity Trypanosoma brucei gambiense

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Trypanosoma brucei gambiense
Confidence	1 — Organism
Curated By	Autocuration

Target

Trypanosoma brucei gambiense (CHEMBL613768) ↗

Type	ORGANISM
Organism	Trypanosoma brucei gambiense

Publication

Recent developments in compounds acting in the DNA minor groove.

Rahman A, O'Sullivan P, Rozas I.
Medchemcomm (2019) 10 : 26 -40
PubMed 30774852 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.00	9.00

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL55	PENTAMIDINE	4.0	1	9.00

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL55	PENTAMIDINE	IC50	=	1.0	nM	9.00