Assay Detail
Binding
CHEMBL4480502
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Inhibition of human MAOB
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of monoamine oxidase inhibitors by medicinal chemistry approaches.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.12 | 7.57 |
| IC50 | 2 | 6.70 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431770 | ISTRADEFYLLINE | 4.0 | 1 | 7.57 |
| CHEMBL26138 | — | — | 1 | 7.00 |
| CHEMBL4527294 | — | — | 1 | 6.70 |
| CHEMBL4536926 | — | — | 1 | 5.47 |
| CHEMBL484470 | — | — | 1 | 4.44 |
| CHEMBL294264 | PURPURIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431770 | ISTRADEFYLLINE | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL26138 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4527294 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4536926 | — | Ki | = | 3420.0 | nM | 5.47 |
| CHEMBL484470 | — | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL294264 | PURPURIN | IC50 | > | 40000.0 | nM | - |