Assay Detail
Functional
CHEMBL4480545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against amantadine-sensitive Influenza A virus (A/chicken/Hubei/327/2004(H5N1)) infected in MDCK cells after 40 mins by crystal violet staining-based plaque reduction assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of heteroaromatic-based benzenesulfonamide derivatives as potent inhibitors of H5N1 influenza A virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 35 | 5.34 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1200340 | OSELTAMIVIR PHOSPHATE | 4.0 | 1 | 6.41 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 6.37 |
| CHEMBL4527406 | — | — | 1 | 6.33 |
| CHEMBL4557613 | — | — | 1 | 6.21 |
| CHEMBL4586535 | — | — | 1 | 6.16 |
| CHEMBL4517321 | — | — | 1 | 5.97 |
| CHEMBL4518980 | — | — | 1 | 5.89 |
| CHEMBL4557215 | — | — | 1 | 5.86 |
| CHEMBL4534199 | — | — | 1 | 5.86 |
| CHEMBL4544193 | — | — | 1 | 5.83 |
| CHEMBL4592186 | — | — | 1 | 5.75 |
| CHEMBL4528685 | — | — | 1 | 5.72 |
| CHEMBL4579348 | — | — | 1 | 5.70 |
| CHEMBL4588491 | — | — | 1 | 5.47 |
| CHEMBL4586595 | — | — | 1 | 5.39 |
| CHEMBL4527371 | — | — | 1 | 5.14 |
| CHEMBL4574356 | — | — | 1 | 5.09 |
| CHEMBL4567651 | — | — | 1 | 4.98 |
| CHEMBL4538304 | — | — | 1 | 4.92 |
| CHEMBL4581693 | — | — | 1 | 4.69 |
| CHEMBL4564406 | — | — | 1 | 4.41 |
| CHEMBL4543160 | — | — | 1 | 4.39 |
| CHEMBL4537555 | — | — | 1 | 4.38 |
| CHEMBL4559127 | — | — | 1 | 4.35 |
| CHEMBL4590782 | — | — | 1 | 4.33 |
| CHEMBL4514902 | — | — | 1 | 4.30 |
| CHEMBL4540325 | — | — | 1 | 4.16 |
| CHEMBL4543323 | — | — | 1 | - |
| CHEMBL4591526 | — | — | 1 | - |
| CHEMBL4546727 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1200340 | OSELTAMIVIR PHOSPHATE | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL660 | AMANTADINE | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4527406 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4557613 | — | EC50 | = | 620.0 | nM | 6.21 |
| CHEMBL4586535 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4517321 | — | EC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4518980 | — | EC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL4557215 | — | EC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL4534199 | — | EC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4544193 | — | EC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL4592186 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4528685 | — | EC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL4579348 | — | EC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4588491 | — | EC50 | = | 3420.0 | nM | 5.47 |
| CHEMBL4586595 | — | EC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL4527371 | — | EC50 | = | 7220.0 | nM | 5.14 |
| CHEMBL4574356 | — | EC50 | = | 8080.0 | nM | 5.09 |
| CHEMBL4567651 | — | EC50 | = | 10490.0 | nM | 4.98 |
| CHEMBL4538304 | — | EC50 | = | 12040.0 | nM | 4.92 |
| CHEMBL4581693 | — | EC50 | = | 20280.0 | nM | 4.69 |
| CHEMBL4564406 | — | EC50 | = | 38560.0 | nM | 4.41 |
| CHEMBL4543160 | — | EC50 | = | 40700.0 | nM | 4.39 |
| CHEMBL4537555 | — | EC50 | = | 41960.0 | nM | 4.38 |
| CHEMBL4559127 | — | EC50 | = | 44830.0 | nM | 4.35 |
| CHEMBL4590782 | — | EC50 | = | 47190.0 | nM | 4.33 |
| CHEMBL4514902 | — | EC50 | = | 49970.0 | nM | 4.30 |
| CHEMBL4540325 | — | EC50 | = | 70050.0 | nM | 4.16 |
| CHEMBL4543323 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4591526 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4546727 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4519600 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4539682 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4551543 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4518870 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4515951 | — | EC50 | > | 100000.0 | nM | - |