Assay Detail
Binding
CHEMBL4480674
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NFkappaB (unknown origin) expressed in human A549 cells co-transfected with pNFkappaB-Luc vector assessed as reduction in TNFalpha-induced NFkappaB transcriptional activity co-incubated for 7 hrs in presence of TNFalpha by bright-glo luciferase reporter gene assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and discovery of asiatic acid based 1,2,3-triazole derivatives as antitumor agents blocking NF-κB activation and cell migration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.40 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4527184 | — | — | 1 | 6.85 |
| CHEMBL4536080 | — | — | 1 | 6.64 |
| CHEMBL4584388 | — | — | 1 | 6.04 |
| CHEMBL4546759 | — | — | 1 | 5.97 |
| CHEMBL536151 | IMD-0354 | 1.0 | 1 | 5.90 |
| CHEMBL4569827 | — | — | 1 | 5.73 |
| CHEMBL4569938 | — | — | 1 | 5.48 |
| CHEMBL4588898 | — | — | 1 | 5.32 |
| CHEMBL4574466 | — | — | 1 | 5.27 |
| CHEMBL4568908 | — | — | 1 | 5.11 |
| CHEMBL4544481 | — | — | 1 | 5.09 |
| CHEMBL4540546 | — | — | 1 | 4.97 |
| CHEMBL4537215 | — | — | 1 | 4.92 |
| CHEMBL4558718 | — | — | 1 | 4.88 |
| CHEMBL4589018 | — | — | 1 | 4.82 |
| CHEMBL4526855 | — | — | 1 | 4.76 |
| CHEMBL4553112 | — | — | 1 | 4.72 |
| CHEMBL4592953 | — | — | 1 | 4.70 |
| CHEMBL4573939 | — | — | 1 | - |
| CHEMBL4548785 | — | — | 1 | - |
| CHEMBL4530301 | — | — | 1 | - |
| CHEMBL404313 | ASIATIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4527184 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4536080 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4584388 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4546759 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL536151 | IMD-0354 | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4569827 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL4569938 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL4588898 | — | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL4574466 | — | IC50 | = | 5390.0 | nM | 5.27 |
| CHEMBL4568908 | — | IC50 | = | 7860.0 | nM | 5.11 |
| CHEMBL4544481 | — | IC50 | = | 8170.0 | nM | 5.09 |
| CHEMBL4540546 | — | IC50 | = | 10610.0 | nM | 4.97 |
| CHEMBL4537215 | — | IC50 | = | 12150.0 | nM | 4.92 |
| CHEMBL4558718 | — | IC50 | = | 13280.0 | nM | 4.88 |
| CHEMBL4589018 | — | IC50 | = | 15040.0 | nM | 4.82 |
| CHEMBL4526855 | — | IC50 | = | 17260.0 | nM | 4.76 |
| CHEMBL4553112 | — | IC50 | = | 18840.0 | nM | 4.72 |
| CHEMBL4592953 | — | IC50 | = | 19790.0 | nM | 4.70 |
| CHEMBL4573939 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4548785 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4530301 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL404313 | ASIATIC ACID | IC50 | > | 20000.0 | nM | - |