Assay Detail
Functional
CHEMBL4480684
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Cytotoxicity against human NCI-H460 cells after 48 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and discovery of asiatic acid based 1,2,3-triazole derivatives as antitumor agents blocking NF-κB activation and cell migration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.75 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.10 |
| CHEMBL4527184 | — | — | 1 | 5.35 |
| CHEMBL4536080 | — | — | 1 | 5.11 |
| CHEMBL4584388 | — | — | 1 | 5.01 |
| CHEMBL4546759 | — | — | 1 | 4.93 |
| CHEMBL4569827 | — | — | 1 | 4.92 |
| CHEMBL4569938 | — | — | 1 | 4.80 |
| CHEMBL4588898 | — | — | 1 | 4.72 |
| CHEMBL4574466 | — | — | 1 | 4.68 |
| CHEMBL4544481 | — | — | 1 | 4.63 |
| CHEMBL4568908 | — | — | 1 | 4.60 |
| CHEMBL4540546 | — | — | 1 | 4.57 |
| CHEMBL4558718 | — | — | 1 | 4.46 |
| CHEMBL4537215 | — | — | 1 | 4.46 |
| CHEMBL4589018 | — | — | 1 | 4.46 |
| CHEMBL4526855 | — | — | 1 | 4.40 |
| CHEMBL4553112 | — | — | 1 | 4.39 |
| CHEMBL4592953 | — | — | 1 | 4.36 |
| CHEMBL404313 | ASIATIC ACID | — | 1 | 4.35 |
| CHEMBL4573939 | — | — | 1 | - |
| CHEMBL4548785 | — | — | 1 | - |
| CHEMBL4530301 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4527184 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL4536080 | — | IC50 | = | 7850.0 | nM | 5.11 |
| CHEMBL4584388 | — | IC50 | = | 9650.0 | nM | 5.01 |
| CHEMBL4546759 | — | IC50 | = | 11740.0 | nM | 4.93 |
| CHEMBL4569827 | — | IC50 | = | 12050.0 | nM | 4.92 |
| CHEMBL4569938 | — | IC50 | = | 15920.0 | nM | 4.80 |
| CHEMBL4588898 | — | IC50 | = | 19060.0 | nM | 4.72 |
| CHEMBL4574466 | — | IC50 | = | 20780.0 | nM | 4.68 |
| CHEMBL4544481 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL4568908 | — | IC50 | = | 24960.0 | nM | 4.60 |
| CHEMBL4540546 | — | IC50 | = | 26840.0 | nM | 4.57 |
| CHEMBL4558718 | — | IC50 | = | 34880.0 | nM | 4.46 |
| CHEMBL4537215 | — | IC50 | = | 34490.0 | nM | 4.46 |
| CHEMBL4589018 | — | IC50 | = | 34630.0 | nM | 4.46 |
| CHEMBL4526855 | — | IC50 | = | 39730.0 | nM | 4.40 |
| CHEMBL4553112 | — | IC50 | = | 40910.0 | nM | 4.39 |
| CHEMBL4592953 | — | IC50 | = | 43570.0 | nM | 4.36 |
| CHEMBL404313 | ASIATIC ACID | IC50 | = | 44820.0 | nM | 4.35 |
| CHEMBL4573939 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4548785 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4530301 | — | IC50 | > | 50000.0 | nM | - |