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Assay Detail

CHEMBL4480800

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Trypanosoma cruzi apoenzyme form of PFK
ChEMBL ↗
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Trypanosoma cruzi
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545) ↗
Type UNCHECKED

Publication

Design, synthesis and molecular docking studies of novel N-arylsulfonyl-benzimidazoles with anti Trypanosoma cruzi activity.
Miana GE, Ribone SR, Vera DMA, Sánchez-Moreno M, Mazzieri MR, Quevedo MA.
Eur J Med Chem (2019) 165 : 1 -10
PubMed 30641409 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 46 4.26 4.56

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3108855 — — 1 4.56
CHEMBL4551736 — — 1 4.43
CHEMBL1519988 — — 1 4.38
CHEMBL4570536 — — 1 4.37
CHEMBL3108853 — — 1 4.31
CHEMBL3108851 — — 1 4.31
CHEMBL3108842 — — 1 4.31
CHEMBL1493289 — — 1 4.23
CHEMBL3108857 — — 1 4.21
CHEMBL3108836 — — 1 4.21
CHEMBL3108831 — — 1 4.21
CHEMBL3108845 — — 1 4.21
CHEMBL3108832 — — 1 4.16
CHEMBL4519223 — — 1 4.14
CHEMBL3108866 — — 1 4.11
CHEMBL3108854 — — 1 4.06
CHEMBL4534114 — — 1 -
CHEMBL1729716 — — 1 -
CHEMBL3112679 — — 1 -
CHEMBL3108859 — — 1 -
CHEMBL3108847 — — 1 -
CHEMBL3108848 — — 1 -
CHEMBL1394402 — — 1 -
CHEMBL3108870 — — 1 -
CHEMBL3108858 — — 1 -
CHEMBL3108868 — — 1 -
CHEMBL1890994 — — 1 -
CHEMBL3108869 — — 1 -
CHEMBL3108867 — — 1 -
CHEMBL3108841 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3108855 — IC50 = 27542.29 nM 4.56
CHEMBL4551736 — IC50 = 37153.52 nM 4.43
CHEMBL1519988 — IC50 = 41686.94 nM 4.38
CHEMBL4570536 — IC50 = 42657.95 nM 4.37
CHEMBL3108853 — IC50 = 48977.88 nM 4.31
CHEMBL3108851 — IC50 = 48977.88 nM 4.31
CHEMBL3108842 — IC50 = 48977.88 nM 4.31
CHEMBL1493289 — IC50 = 58884.37 nM 4.23
CHEMBL3108857 — IC50 = 61659.5 nM 4.21
CHEMBL3108836 — IC50 = 61659.5 nM 4.21
CHEMBL3108831 — IC50 = 61659.5 nM 4.21
CHEMBL3108845 — IC50 = 61659.5 nM 4.21
CHEMBL3108832 — IC50 = 69183.1 nM 4.16
CHEMBL4519223 — IC50 = 72443.6 nM 4.14
CHEMBL3108866 — IC50 = 77624.71 nM 4.11
CHEMBL3108854 — IC50 = 87096.36 nM 4.06
CHEMBL4583963 — IC50 = 218776.16 nM -
CHEMBL4580128 — IC50 = 389045.14 nM -
CHEMBL4535715 — IC50 = 162181.01 nM -
CHEMBL4519623 — IC50 = 331131.12 nM -
CHEMBL3108846 — IC50 = 1096478.2 nM -
CHEMBL3108850 — IC50 = 154881.66 nM -
CHEMBL3108849 — IC50 = 154881.66 nM -
CHEMBL1439907 — IC50 = 181970.09 nM -
CHEMBL3108837 — IC50 = 309029.54 nM -
CHEMBL3108843 — IC50 = 346736.85 nM -
CHEMBL3108839 — IC50 = 389045.14 nM -
CHEMBL3108852 — IC50 = 489778.82 nM -
CHEMBL3108865 — IC50 = 549540.87 nM -
CHEMBL3108844 — IC50 = 616595.0 nM -
CHEMBL3108835 — IC50 = 691830.97 nM -
CHEMBL3108860 — IC50 = 870963.59 nM -
CHEMBL3108841 — IC50 = 218776.16 nM -
CHEMBL3108867 — IC50 = 24547089.16 nM -
CHEMBL3108869 — IC50 = 19054607.18 nM -
CHEMBL1890994 — IC50 = 120226.44 nM -
CHEMBL3108868 — IC50 = 8511380.38 nM -
CHEMBL3108858 — IC50 = 7762471.17 nM -
CHEMBL3108870 — IC50 = 5888436.55 nM -
CHEMBL1394402 — IC50 = 4365158.32 nM -
CHEMBL3108848 — IC50 = 2187761.62 nM -
CHEMBL3108847 — IC50 = 1548816.62 nM -
CHEMBL3108859 — IC50 = 1380384.26 nM -
CHEMBL3112679 — IC50 = 112201.85 nM -
CHEMBL1729716 — IC50 = 138038.43 nM -
CHEMBL4534114 — IC50 = 457088.19 nM -