Assay Detail
Functional
CHEMBL4480803
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Cytotoxicity against mouse CT26.WT cells after 72 hrs by MTT assay
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CT26.WT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 4.66 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 6.38 |
| CHEMBL4520590 | — | — | 1 | 5.80 |
| CHEMBL4549285 | — | — | 1 | 5.47 |
| CHEMBL4576092 | — | — | 1 | 5.41 |
| CHEMBL4537958 | — | — | 1 | 5.20 |
| CHEMBL4579706 | — | — | 1 | 5.11 |
| CHEMBL4572453 | — | — | 1 | 5.08 |
| CHEMBL4575358 | — | — | 1 | 5.02 |
| CHEMBL4564492 | — | — | 1 | 4.93 |
| CHEMBL4562698 | — | — | 1 | 4.92 |
| CHEMBL4560517 | — | — | 1 | 4.81 |
| CHEMBL4583999 | — | — | 1 | 4.81 |
| CHEMBL4543578 | — | — | 1 | 4.71 |
| CHEMBL4585342 | — | — | 1 | 4.66 |
| CHEMBL4585976 | — | — | 1 | 4.66 |
| CHEMBL4543692 | — | — | 1 | 4.65 |
| CHEMBL4547329 | — | — | 1 | 4.62 |
| CHEMBL4570866 | — | — | 1 | 4.61 |
| CHEMBL4529515 | — | — | 1 | 4.61 |
| CHEMBL4566444 | — | — | 1 | 4.60 |
| CHEMBL4539509 | — | — | 1 | 4.55 |
| CHEMBL4538414 | — | — | 1 | 4.54 |
| CHEMBL4513417 | — | — | 1 | 4.52 |
| CHEMBL4567283 | — | — | 1 | 4.42 |
| CHEMBL4539974 | — | — | 1 | 4.33 |
| CHEMBL4546443 | — | — | 1 | 4.30 |
| CHEMBL4541668 | — | — | 1 | 4.27 |
| CHEMBL4554581 | — | — | 1 | 4.25 |
| CHEMBL4545028 | — | — | 1 | 4.22 |
| CHEMBL4589665 | — | — | 1 | 4.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4520590 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4549285 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4576092 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4537958 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4579706 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4572453 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4575358 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4564492 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL4562698 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4560517 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL4583999 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL4543578 | — | IC50 | = | 19400.0 | nM | 4.71 |
| CHEMBL4585976 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL4585342 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL4543692 | — | IC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL4547329 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL4570866 | — | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL4529515 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL4566444 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL4539509 | — | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL4538414 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL4513417 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL4567283 | — | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL4539974 | — | IC50 | = | 46500.0 | nM | 4.33 |
| CHEMBL4546443 | — | IC50 | = | 50600.0 | nM | 4.30 |
| CHEMBL4541668 | — | IC50 | = | 54200.0 | nM | 4.27 |
| CHEMBL4554581 | — | IC50 | = | 55700.0 | nM | 4.25 |
| CHEMBL4545028 | — | IC50 | = | 59500.0 | nM | 4.22 |
| CHEMBL4589665 | — | IC50 | = | 61300.0 | nM | 4.21 |
| CHEMBL4565669 | — | IC50 | = | 63800.0 | nM | 4.20 |
| CHEMBL4584654 | — | IC50 | = | 69500.0 | nM | 4.16 |
| CHEMBL4586733 | — | IC50 | = | 69700.0 | nM | 4.16 |
| CHEMBL4534874 | — | IC50 | = | 77700.0 | nM | 4.11 |
| CHEMBL4569063 | — | IC50 | = | 84300.0 | nM | 4.07 |
| CHEMBL4577045 | — | IC50 | = | 93300.0 | nM | 4.03 |
| CHEMBL4560572 | — | IC50 | = | 96500.0 | nM | 4.01 |
| CHEMBL4533020 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4538065 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4533079 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4537437 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4554732 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4513563 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4555595 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4589031 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4555208 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4537353 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4527907 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4590572 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4544920 | — | IC50 | > | 100000.0 | nM | - |