Assay Detail
Functional
CHEMBL4480966
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Cytotoxicity against human K562 cells after 72 hrs by MTT assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.61 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4592400 | — | — | 1 | 6.34 |
| CHEMBL4587009 | — | — | 1 | 6.17 |
| CHEMBL4521851 | — | — | 1 | 6.12 |
| CHEMBL4522076 | — | — | 1 | 6.12 |
| CHEMBL4587116 | — | — | 1 | 6.10 |
| CHEMBL4564124 | — | — | 1 | 6.07 |
| CHEMBL4522322 | — | — | 1 | 6.02 |
| CHEMBL4552164 | — | — | 1 | 6.01 |
| CHEMBL4580459 | — | — | 1 | 6.01 |
| CHEMBL4585496 | — | — | 1 | 6.00 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.99 |
| CHEMBL4532225 | — | — | 1 | 5.98 |
| CHEMBL4483767 | — | — | 1 | 5.94 |
| CHEMBL4590861 | — | — | 1 | 5.89 |
| CHEMBL4565324 | — | — | 1 | 5.89 |
| CHEMBL4561935 | — | — | 1 | 5.86 |
| CHEMBL4573022 | — | — | 1 | 5.82 |
| CHEMBL4562143 | — | — | 1 | 5.81 |
| CHEMBL4553974 | — | — | 1 | 5.71 |
| CHEMBL4591861 | — | — | 1 | 5.69 |
| CHEMBL4537554 | — | — | 1 | 5.57 |
| CHEMBL4526822 | — | — | 1 | 5.48 |
| CHEMBL4540173 | — | — | 1 | 5.37 |
| CHEMBL4527771 | — | — | 1 | 5.36 |
| CHEMBL4590949 | — | — | 1 | 5.35 |
| CHEMBL4589953 | — | — | 1 | 5.26 |
| CHEMBL4563431 | — | — | 1 | 5.23 |
| CHEMBL4538567 | — | — | 1 | 5.20 |
| CHEMBL4577864 | — | — | 1 | 5.14 |
| CHEMBL4572166 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4592400 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4587009 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL4521851 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4522076 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4587116 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL4564124 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL4522322 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4552164 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4580459 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4585496 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4532225 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL4483767 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL4590861 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL4565324 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL4561935 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4573022 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL4562143 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4553974 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4591861 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL4537554 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL4526822 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL4540173 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL4527771 | — | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL4590949 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL4589953 | — | IC50 | = | 5490.0 | nM | 5.26 |
| CHEMBL4563431 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL4538567 | — | IC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL4577864 | — | IC50 | = | 7210.0 | nM | 5.14 |
| CHEMBL4572166 | — | IC50 | = | 10130.0 | nM | 4.99 |
| CHEMBL4483353 | — | IC50 | = | 10810.0 | nM | 4.97 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 12210.0 | nM | 4.91 |
| CHEMBL4529765 | — | IC50 | = | 14360.0 | nM | 4.84 |
| CHEMBL4552860 | — | IC50 | = | 25740.0 | nM | 4.59 |
| CHEMBL4543337 | — | IC50 | = | 40270.0 | nM | 4.39 |