Assay Detail
Functional
CHEMBL4480972
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human Bel7042 cells after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.81 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4592400 | — | — | 1 | 6.38 |
| CHEMBL4587009 | — | — | 1 | 6.25 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.19 |
| CHEMBL4522076 | — | — | 1 | 6.13 |
| CHEMBL4580459 | — | — | 1 | 6.03 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 5.88 |
| CHEMBL4587116 | — | — | 1 | 5.87 |
| CHEMBL4521851 | — | — | 1 | 5.64 |
| CHEMBL4564124 | — | — | 1 | 5.53 |
| CHEMBL4585496 | — | — | 1 | 5.35 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4592400 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4587009 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4522076 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4580459 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL4587116 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL4521851 | — | IC50 | = | 2310.0 | nM | 5.64 |
| CHEMBL4564124 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL4585496 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 22920.0 | nM | 4.64 |