Assay Detail
Functional
CHEMBL4480973
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human Bel7402/5-FU cells after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Bel7402/5-FU |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.88 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4592400 | — | — | 1 | 6.54 |
| CHEMBL4587009 | — | — | 1 | 6.51 |
| CHEMBL4522076 | — | — | 1 | 6.24 |
| CHEMBL4521851 | — | — | 1 | 6.14 |
| CHEMBL4580459 | — | — | 1 | 6.12 |
| CHEMBL4587116 | — | — | 1 | 5.95 |
| CHEMBL4564124 | — | — | 1 | 5.81 |
| CHEMBL4585496 | — | — | 1 | 5.54 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 4.98 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 4.96 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4592400 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4587009 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4522076 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4521851 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL4580459 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL4587116 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL4564124 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4585496 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 10540.0 | nM | 4.98 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 10950.0 | nM | 4.96 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 935780.0 | nM | - |