Assay Detail
Binding
CHEMBL4481004
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Inhibition of PARP1 (unknown origin)
7
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Medicinal chemistry approaches of poly ADP-Ribose polymerase 1 (PARP1) inhibitors as anticancer agents - A recent update.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.48 | 8.42 |
| Ki | 3 | 7.04 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1094636 | NIRAPARIB | 4.0 | 2 | 8.49 |
| CHEMBL4569989 | — | — | 1 | 8.00 |
| CHEMBL123904 | — | — | 1 | 7.32 |
| CHEMBL4521985 | — | — | 1 | 7.10 |
| CHEMBL125200 | — | — | 1 | 6.38 |
| CHEMBL81977 | 3-AMINOBENZAMIDE | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1094636 | NIRAPARIB | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL1094636 | NIRAPARIB | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL4569989 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL123904 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL4521985 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL125200 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL81977 | 3-AMINOBENZAMIDE | Ki | = | 5000.0 | nM | 5.30 |