Assay Detail
Binding
CHEMBL4481007
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PARP1 (unknown origin) after 1 min in presence of NAD by top count analysis
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Medicinal chemistry approaches of poly ADP-Ribose polymerase 1 (PARP1) inhibitors as anticancer agents - A recent update.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 8.92 | 8.92 |
| IC50 | 1 | 9.24 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | 4.0 | 2 | 9.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3137320 | TALAZOPARIB | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL3137320 | TALAZOPARIB | Ki | = | 1.2 | nM | 8.92 |