Assay Detail
Binding
CHEMBL4481093
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to DPP4 (unknown origin) expressed in baculovirus expressing system
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Natural-Product-Derived Preclinical Candidate for Once-Weekly Treatment of Type 2 Diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 8.71 | 9.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4550812 | — | — | 1 | 9.75 |
| CHEMBL3941804 | — | — | 1 | 8.62 |
| CHEMBL2105762 | OMARIGLIPTIN | 4.0 | 1 | 8.56 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4550812 | — | Kd | = | 0.177 | nM | 9.75 |
| CHEMBL3941804 | — | Kd | = | 2.38 | nM | 8.62 |
| CHEMBL2105762 | OMARIGLIPTIN | Kd | = | 2.75 | nM | 8.56 |
| CHEMBL1422 | SITAGLIPTIN | Kd | = | 12.7 | nM | 7.90 |