Assay Detail
Functional
CHEMBL4481287
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human RBC assessed as reduction in parasite growth after 35 to 56 hrs by nucleic acid staining based flow cytometry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.68 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.64 |
| CHEMBL172 | (S,R)-MEFLOQUINE | — | 1 | 8.21 |
| CHEMBL1255726 | — | — | 1 | 7.33 |
| CHEMBL303933 | PIPERAQUINE | 3.0 | 1 | 7.29 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361497 | ARTESUNATE | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL172 | (S,R)-MEFLOQUINE | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL1255726 | — | IC50 | = | 46.5 | nM | 7.33 |
| CHEMBL303933 | PIPERAQUINE | IC50 | = | 50.8 | nM | 7.29 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 111.2 | nM | 6.95 |