Assay Detail
Binding
CHEMBL4481382
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Inhibition of human FPPS using IPP and GPP
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.75 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494897 | — | — | 1 | 7.00 |
| CHEMBL494279 | — | — | 1 | 6.64 |
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 6.60 |
| CHEMBL493443 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494897 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL494279 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL493443 | — | IC50 | = | 550000.0 | nM | - |