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Assay Detail

CHEMBL4481393

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Functional
Antimicrobial activity against Wolbachia pipientis infected in Asian tiger mosquito C6/36 cells after 7 days by SYTO11 DNA dye-based confocal imaging analysis
ChEMBL ↗
72
Total Activities
72
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Wolbachia
Confidence 1 — Organism
Curated By Autocuration

Target

Wolbachia (CHEMBL4630676) ↗
Type ORGANISM
Organism Wolbachia

Publication

Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis.
Jacobs RT, Lunde CS, Freund YR, Hernandez V, Li X, Xia Y, Carter DS, Berry PW, Halladay J, Rock F, Stefanakis R, Easom E, Plattner JJ, Ford L, Johnston KL, Cook DAN, Clare R, Cassidy A, Myhill L, Tyrer H, Gamble J, Guimaraes AF, Steven A, Lenz F, Ehrens A, Frohberger SJ, Koschel M, Hoerauf A, Hübner MP, McNamara CW, Bakowski MA, Turner JD, Taylor MJ, Ward SA.
J Med Chem (2019) 62 : 2521 -2540
PubMed 30730745 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 71 7.20 9.15
IC50 1 6.71 6.71

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4483699 — — 1 9.15
CHEMBL4542784 — — 1 8.82
CHEMBL4557144 — — 1 8.46
CHEMBL4566922 — — 1 8.40
CHEMBL4589897 — — 1 8.30
CHEMBL4532724 — — 1 8.20
CHEMBL4585474 — — 1 8.08
CHEMBL4578840 — — 1 8.05
CHEMBL4551336 — — 1 7.96
CHEMBL4522659 — — 1 7.92
CHEMBL4575394 — — 1 7.85
CHEMBL4552978 — — 1 7.83
CHEMBL4535824 — — 1 7.82
CHEMBL4552381 — — 1 7.64
CHEMBL4561712 — — 1 7.58
CHEMBL4553678 — — 1 7.50
CHEMBL4525311 — — 1 7.42
CHEMBL4592079 — — 1 7.30
CHEMBL4539733 — — 1 7.28
CHEMBL4519273 — — 1 7.19
CHEMBL4565868 — — 1 7.00
CHEMBL4535683 — — 1 7.00
CHEMBL4527402 — — 1 6.98
CHEMBL4522642 — — 1 6.97
CHEMBL4552098 — — 1 6.97
CHEMBL4529660 — — 1 6.95
CHEMBL4544063 — — 1 6.94
CHEMBL4587910 — — 1 6.91
CHEMBL4547028 — — 1 6.83
CHEMBL4580565 — — 1 6.83

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4483699 — EC50 = 0.7 nM 9.15
CHEMBL4542784 — EC50 = 1.5 nM 8.82
CHEMBL4557144 — EC50 = 3.5 nM 8.46
CHEMBL4566922 — EC50 = 4.0 nM 8.40
CHEMBL4589897 — EC50 = 5.0 nM 8.30
CHEMBL4532724 — EC50 = 6.3 nM 8.20
CHEMBL4585474 — EC50 = 8.4 nM 8.08
CHEMBL4578840 — EC50 = 9.0 nM 8.05
CHEMBL4551336 — EC50 = 11.0 nM 7.96
CHEMBL4522659 — EC50 = 12.0 nM 7.92
CHEMBL4575394 — EC50 = 14.2 nM 7.85
CHEMBL4552978 — EC50 = 14.8 nM 7.83
CHEMBL4535824 — EC50 = 15.0 nM 7.82
CHEMBL4552381 — EC50 = 23.0 nM 7.64
CHEMBL4561712 — EC50 = 26.1 nM 7.58
CHEMBL4553678 — EC50 = 32.0 nM 7.50
CHEMBL4525311 — EC50 = 38.0 nM 7.42
CHEMBL4592079 — EC50 = 50.0 nM 7.30
CHEMBL4539733 — EC50 = 52.0 nM 7.28
CHEMBL4519273 — EC50 = 64.0 nM 7.19
CHEMBL4565868 — EC50 = 100.0 nM 7.00
CHEMBL4535683 — EC50 = 101.0 nM 7.00
CHEMBL4527402 — EC50 = 104.0 nM 6.98
CHEMBL4522642 — EC50 = 107.0 nM 6.97
CHEMBL4552098 — EC50 = 106.0 nM 6.97
CHEMBL4529660 — EC50 = 113.0 nM 6.95
CHEMBL4544063 — EC50 = 115.0 nM 6.94
CHEMBL4587910 — EC50 = 123.0 nM 6.91
CHEMBL4547028 — EC50 = 148.0 nM 6.83
CHEMBL4580565 — EC50 = 149.0 nM 6.83
CHEMBL4518696 — EC50 = 158.0 nM 6.80
CHEMBL4533414 — EC50 = 164.0 nM 6.79
CHEMBL4540795 — EC50 = 172.0 nM 6.76
CHEMBL4548875 — EC50 = 197.0 nM 6.71
CHEMBL4559425 — EC50 = 197.0 nM 6.71
CHEMBL4542505 — IC50 = 193.0 nM 6.71
CHEMBL3291398 LEFAMULIN EC50 = 205.0 nM 6.69
CHEMBL4576039 — EC50 = 215.0 nM 6.67
CHEMBL4592244 — EC50 = 229.0 nM 6.64
CHEMBL4576782 — EC50 = 240.0 nM 6.62
CHEMBL4515909 — EC50 = 257.0 nM 6.59
CHEMBL4520153 — EC50 = 278.0 nM 6.56
CHEMBL4527454 — EC50 = 298.0 nM 6.53
CHEMBL4573752 — EC50 = 302.0 nM 6.52
CHEMBL1234521 TIAMULIN EC50 = 317.0 nM 6.50
CHEMBL4558232 — EC50 = 328.0 nM 6.48
CHEMBL4546281 — EC50 = 329.0 nM 6.48
CHEMBL4584175 — EC50 = 357.0 nM 6.45
CHEMBL4514464 — EC50 = 372.0 nM 6.43
CHEMBL4521532 — EC50 = 409.0 nM 6.39