Assay Detail
Binding
CHEMBL4481497
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Displacement of [3H]NCS382 from high-affinity GHB binding site of alpha4betadelta receptor in mouse brain membranes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Brain |
| Subcellular | Membranes |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 2-(Imidazo[1,2- b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 4.80 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32503 | GABAZINE | — | 1 | 4.80 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32503 | GABAZINE | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | Ki | = | 2100000.0 | nM | - |