Assay Detail
Binding
CHEMBL4481718
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Antagonist activity at histamine H1 receptor in guinea-pig ileum assessed as inhibition of histamine-induced contractions after 15 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Alkyl derivatives of 1,3,5-triazine as histamine H<sub>4</sub> receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 6.39 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1305 | ANTAZOLINE | 4.0 | 1 | 7.14 |
| CHEMBL129198 | JNJ-7777120 | — | 1 | 6.11 |
| CHEMBL4483783 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1305 | ANTAZOLINE | Kd | = | 72.44 | nM | 7.14 |
| CHEMBL129198 | JNJ-7777120 | Kd | = | 776.25 | nM | 6.11 |
| CHEMBL4483783 | — | Kd | = | 1230.27 | nM | 5.91 |