Assay Detail
Binding
CHEMBL4481758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3,5-Dialkoxypyridine analogues of bedaquiline are potent antituberculosis agents with minimal inhibition of the hERG channel.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.33 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4543900 | — | — | 1 | 5.80 |
| CHEMBL376488 | BEDAQUILINE | 4.0 | 1 | 5.80 |
| CHEMBL4574425 | — | — | 1 | 5.77 |
| CHEMBL4593713 | — | — | 1 | 5.66 |
| CHEMBL4519972 | — | — | 1 | 5.66 |
| CHEMBL4570895 | — | — | 1 | 5.62 |
| CHEMBL4578975 | — | — | 1 | 5.58 |
| CHEMBL4553350 | — | — | 1 | 5.51 |
| CHEMBL4519008 | — | — | 1 | 5.36 |
| CHEMBL4586271 | — | — | 1 | 5.35 |
| CHEMBL4561342 | — | — | 1 | 5.35 |
| CHEMBL4532620 | — | — | 1 | 5.26 |
| CHEMBL4585644 | — | — | 1 | 5.24 |
| CHEMBL4537029 | — | — | 1 | 5.23 |
| CHEMBL4591849 | — | — | 1 | 5.03 |
| CHEMBL4565089 | — | — | 1 | 5.00 |
| CHEMBL4534204 | — | — | 1 | 5.00 |
| CHEMBL4550410 | — | — | 1 | 4.97 |
| CHEMBL4590996 | — | — | 1 | 4.96 |
| CHEMBL4529465 | TBAJ-587 | 1.0 | 1 | 4.89 |
| CHEMBL4554862 | — | — | 1 | 4.88 |
| CHEMBL4524270 | — | — | 1 | - |
| CHEMBL4548735 | — | — | 1 | - |
| CHEMBL4525464 | — | — | 1 | - |
| CHEMBL4580150 | — | — | 1 | - |
| CHEMBL4543668 | — | — | 1 | - |
| CHEMBL4553146 | TBAJ-876 | 2.0 | 1 | - |
| CHEMBL4551182 | — | — | 1 | - |
| CHEMBL4530411 | — | — | 1 | - |
| CHEMBL4542973 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4543900 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL376488 | BEDAQUILINE | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4574425 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4593713 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4519972 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4570895 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4578975 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4553350 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4519008 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4586271 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4561342 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4532620 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4585644 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4537029 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4591849 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4565089 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4534204 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL4550410 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4590996 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4529465 | TBAJ-587 | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4554862 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL4560398 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4531693 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4555888 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4569766 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4530550 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4542973 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4530411 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4551182 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4553146 | TBAJ-876 | IC50 | > | 30000.0 | nM | - |
| CHEMBL4543668 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4580150 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4525464 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4548735 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4524270 | — | IC50 | > | 10000.0 | nM | - |