Assay Detail
Binding
CHEMBL4481777
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]PSB11 from recombinant human adenosine A3 receptor expressed in CHO cells
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 40 | 5.02 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431770 | ISTRADEFYLLINE | 4.0 | 1 | 5.35 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.88 |
| CHEMBL241618 | — | — | 1 | 4.82 |
| CHEMBL4546819 | — | — | 1 | - |
| CHEMBL4540760 | — | — | 1 | - |
| CHEMBL4554404 | — | — | 1 | - |
| CHEMBL4573063 | — | — | 1 | - |
| CHEMBL4574378 | — | — | 1 | - |
| CHEMBL4573517 | — | — | 1 | - |
| CHEMBL4521398 | — | — | 1 | - |
| CHEMBL4563397 | — | — | 1 | - |
| CHEMBL4579395 | — | — | 1 | - |
| CHEMBL4483563 | — | — | 1 | - |
| CHEMBL4549927 | — | — | 1 | - |
| CHEMBL4544530 | — | — | 1 | - |
| CHEMBL4559410 | — | — | 1 | - |
| CHEMBL4569183 | — | — | 1 | - |
| CHEMBL4579508 | — | — | 1 | - |
| CHEMBL4530654 | — | — | 1 | - |
| CHEMBL4550899 | — | — | 1 | - |
| CHEMBL4592888 | — | — | 1 | - |
| CHEMBL4521517 | — | — | 1 | - |
| CHEMBL4563999 | — | — | 1 | - |
| CHEMBL4558859 | — | — | 1 | - |
| CHEMBL4566592 | — | — | 1 | - |
| CHEMBL4560961 | — | — | 1 | - |
| CHEMBL4570974 | — | — | 1 | - |
| CHEMBL4554986 | — | — | 1 | - |
| CHEMBL4517303 | — | — | 1 | - |
| CHEMBL4535750 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431770 | ISTRADEFYLLINE | Ki | = | 4470.0 | nM | 5.35 |
| CHEMBL113 | CAFFEINE | Ki | = | 13300.0 | nM | 4.88 |
| CHEMBL241618 | — | Ki | = | 15200.0 | nM | 4.82 |
| CHEMBL4563397 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4569201 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4521398 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4573517 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4574378 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4573063 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4554404 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4540760 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4546819 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4565406 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4537668 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4533073 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4576786 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4574105 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4531455 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4580206 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4574192 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4517925 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4592888 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4535750 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4517303 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4554986 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4570974 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4560961 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4566592 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4558859 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4563999 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4521517 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4579395 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4550899 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4530654 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4579508 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4569183 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4559410 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4544530 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4549927 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4483563 | — | Ki | > | 1000.0 | nM | - |