Assay Detail
Functional
CHEMBL4482113
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and activity evaluation of indole-based double - Branched HDAC1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.37 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 5.97 |
| CHEMBL4588104 | — | — | 1 | 5.65 |
| CHEMBL4592929 | — | — | 1 | 5.49 |
| CHEMBL4574697 | — | — | 1 | 5.48 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.34 |
| CHEMBL4542734 | — | — | 1 | 5.33 |
| CHEMBL4541704 | — | — | 1 | 5.31 |
| CHEMBL4563800 | — | — | 1 | 5.17 |
| CHEMBL4513524 | — | — | 1 | 5.17 |
| CHEMBL4575399 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408513 | BELINOSTAT | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL4588104 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL4592929 | — | IC50 | = | 3260.0 | nM | 5.49 |
| CHEMBL4574697 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4610.0 | nM | 5.34 |
| CHEMBL4542734 | — | IC50 | = | 4660.0 | nM | 5.33 |
| CHEMBL4541704 | — | IC50 | = | 4910.0 | nM | 5.31 |
| CHEMBL4563800 | — | IC50 | = | 6830.0 | nM | 5.17 |
| CHEMBL4513524 | — | IC50 | = | 6840.0 | nM | 5.17 |
| CHEMBL4575399 | — | IC50 | = | 17400.0 | nM | 4.76 |