Assay Detail
Functional
CHEMBL4482115
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Antiproliferative activity against human PC3 cells after 48 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and activity evaluation of indole-based double - Branched HDAC1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.54 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 5.88 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.73 |
| CHEMBL4574697 | — | — | 1 | 5.71 |
| CHEMBL4592929 | — | — | 1 | 5.70 |
| CHEMBL4588104 | — | — | 1 | 5.63 |
| CHEMBL4542734 | — | — | 1 | 5.51 |
| CHEMBL4563800 | — | — | 1 | 5.49 |
| CHEMBL4541704 | — | — | 1 | 5.46 |
| CHEMBL4513524 | — | — | 1 | 5.34 |
| CHEMBL4575399 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL408513 | BELINOSTAT | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL4574697 | — | IC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL4592929 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4588104 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL4542734 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL4563800 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL4541704 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL4513524 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL4575399 | — | IC50 | = | 11910.0 | nM | 4.92 |