Assay Detail
Binding
CHEMBL4482122
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Inhibition of HDAC8 (unknown origin) using Ac-Leu-GlyLys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition and measured after 30 mins by fluorescence assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and activity evaluation of indole-based double - Branched HDAC1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.75 | 7.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4588104 | — | — | 1 | 7.18 |
| CHEMBL408513 | BELINOSTAT | 4.0 | 1 | 7.17 |
| CHEMBL4563800 | — | — | 1 | 6.64 |
| CHEMBL4574697 | — | — | 1 | 6.61 |
| CHEMBL4592929 | — | — | 1 | 6.55 |
| CHEMBL4542734 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4588104 | — | IC50 | = | 65.7 | nM | 7.18 |
| CHEMBL408513 | BELINOSTAT | IC50 | = | 67.85 | nM | 7.17 |
| CHEMBL4563800 | — | IC50 | = | 229.2 | nM | 6.64 |
| CHEMBL4574697 | — | IC50 | = | 243.1 | nM | 6.61 |
| CHEMBL4592929 | — | IC50 | = | 281.1 | nM | 6.55 |
| CHEMBL4542734 | — | IC50 | = | 423.1 | nM | 6.37 |