Assay Detail
Binding
CHEMBL4482490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse GOAT expressed in HEK293FT cells co-expressing pre-proghrelin assessed as reduction in ghrelin octanoylation incubated for 24 hrs by ELISA
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Ghrelin o-acyltransferase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.98 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762621 | BARDOXOLONE METHYL | 3.0 | 1 | 7.46 |
| CHEMBL3105688 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762621 | BARDOXOLONE METHYL | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3105688 | — | IC50 | = | 320.0 | nM | 6.50 |