Assay Detail
Binding
CHEMBL4482679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His10-tagged mouse GOAT expressed in baculovirus infected Sf9 cells assessed as reduction in specific acyl transfer from tritiated-octanoyl CoA to recombinant His-tagged pro-ghrelin
13
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small molecule inhibitors of ghrelin O-acyltransferase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 11 | - | - |
| IC50 | 2 | 4.94 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4550281 | — | — | 2 | 5.82 |
| CHEMBL4586426 | — | — | 1 | 4.05 |
| CHEMBL4552756 | — | — | 1 | - |
| CHEMBL4549067 | — | — | 1 | - |
| CHEMBL4579550 | — | — | 1 | - |
| CHEMBL4543170 | — | — | 1 | - |
| CHEMBL4558660 | — | — | 1 | - |
| CHEMBL4585229 | — | — | 1 | - |
| CHEMBL4568157 | — | — | 1 | - |
| CHEMBL4553581 | — | — | 1 | - |
| CHEMBL4556712 | — | — | 1 | - |
| CHEMBL4580041 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4550281 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4586426 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL4552756 | — | Inhibition | - | % | - | |
| CHEMBL4550281 | — | Inhibition | - | % | - | |
| CHEMBL4549067 | — | Inhibition | - | % | - | |
| CHEMBL4579550 | — | Inhibition | - | % | - | |
| CHEMBL4543170 | — | Inhibition | - | % | - | |
| CHEMBL4558660 | — | Inhibition | - | % | - | |
| CHEMBL4585229 | — | Inhibition | - | % | - | |
| CHEMBL4568157 | — | Inhibition | - | % | - | |
| CHEMBL4553581 | — | Inhibition | - | % | - | |
| CHEMBL4556712 | — | Inhibition | - | % | - | |
| CHEMBL4580041 | — | Inhibition | - | % | - |