Assay Detail
Binding
CHEMBL4482751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ACAT2 in human HepG2 cells using NBD22-labeled sterol as substrate incubated for 6 hrs by fluorescence based assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Class of tricyclic analogue, preparation method and use thereof
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.90 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4553029 | — | — | 1 | 7.64 |
| CHEMBL4565264 | — | — | 1 | 7.16 |
| CHEMBL4585060 | — | — | 1 | 7.11 |
| CHEMBL4519710 | — | — | 1 | 7.09 |
| CHEMBL4536996 | — | — | 1 | 7.07 |
| CHEMBL4555013 | — | — | 1 | 7.07 |
| CHEMBL4539524 | — | — | 1 | 6.99 |
| CHEMBL4554131 | — | — | 1 | 6.82 |
| CHEMBL4518651 | — | — | 1 | 6.75 |
| CHEMBL4569948 | — | — | 1 | 6.61 |
| CHEMBL4555697 | — | — | 1 | 6.36 |
| CHEMBL4554239 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4553029 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4565264 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4585060 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4519710 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL4536996 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4555013 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4539524 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL4554131 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL4518651 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL4569948 | — | IC50 | = | 245.0 | nM | 6.61 |
| CHEMBL4555697 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL4554239 | — | IC50 | = | 831.0 | nM | 6.08 |