Assay Detail
Binding
CHEMBL4482780
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Uncompetitive inhibition of IDO1 (unknown origin) using L-tryptophan as substrate incubated for 30 min assessed as reduction in conversion of N-formyl kynurenine to kynurenine by dixon plot analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Uses of tryptanthrin and derivative thereof in preparing hldo2 inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.84 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432537 | — | — | 1 | 7.27 |
| CHEMBL1098875 | — | — | 1 | 6.79 |
| CHEMBL72165 | — | — | 1 | 6.41 |
| CHEMBL3087009 | — | — | 1 | 5.26 |
| CHEMBL3087010 | — | — | 1 | 5.01 |
| CHEMBL1276265 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432537 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL1098875 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL72165 | — | Ki | = | 389.0 | nM | 6.41 |
| CHEMBL3087009 | — | Ki | = | 5480.0 | nM | 5.26 |
| CHEMBL3087010 | — | Ki | = | 9650.0 | nM | 5.01 |
| CHEMBL1276265 | — | Ki | = | 49370.0 | nM | 4.31 |