Assay Detail
Binding
CHEMBL4482782
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Uncompetitive inhibition of human IDO2 using L-tryptophan as substrate incubated for 30 min assessed as reduction in conversion of N-formyl kynurenine to kynurenine by dixon plot analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Uses of tryptanthrin and derivative thereof in preparing hldo2 inhibitor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.09 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432537 | — | — | 1 | 6.01 |
| CHEMBL1098875 | — | — | 1 | 5.46 |
| CHEMBL72165 | — | — | 1 | 5.25 |
| CHEMBL306946 | TRYPTANTHRIN | — | 1 | 4.82 |
| CHEMBL3087010 | — | — | 1 | 4.61 |
| CHEMBL1276265 | — | — | 1 | 4.40 |
| CHEMBL3086870 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432537 | — | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL1098875 | — | Ki | = | 3510.0 | nM | 5.46 |
| CHEMBL72165 | — | Ki | = | 5620.0 | nM | 5.25 |
| CHEMBL306946 | TRYPTANTHRIN | Ki | = | 15180.0 | nM | 4.82 |
| CHEMBL3087010 | — | Ki | = | 24620.0 | nM | 4.61 |
| CHEMBL1276265 | — | Ki | = | 39460.0 | nM | 4.40 |
| CHEMBL3086870 | — | Ki | = | 105100.0 | nM | - |